/*
 * Petragen -- precision biotech aesthetic
 * Immersive blue hero, airy surfaces, crisp type, clinical teal accents
 */

:root {
  --color-bg: #f3f6f4;
  --color-bg-subtle: #e8f0eb;
  --color-surface: #ffffff;
  --color-surface-elevated: #f9fbf9;
  --color-border: rgba(20, 48, 40, 0.1);
  --color-text: #142821;
  --color-text-muted: #4d625b;
  --color-accent: #0b6b58;
  --color-accent-hover: #094a3d;
  --color-accent-soft: rgba(11, 107, 88, 0.1);
  --color-accent-muted: #2d8a75;
  --color-warm: #8a5a1c;
  --color-warm-soft: rgba(212, 168, 75, 0.18);
  --color-hero-blue: #082e4e;
  --color-hero-glow: rgba(60, 160, 255, 0.12);
  --font-display: "Fraunces", Georgia, "Times New Roman", serif;
  --font-body: "Plus Jakarta Sans", system-ui, -apple-system, sans-serif;
  --space-xs: 0.35rem;
  --space-sm: 0.75rem;
  --space-md: 1.25rem;
  --space-lg: 2rem;
  --space-xl: 3rem;
  --space-2xl: 4.5rem;
  --radius: 14px;
  --radius-pill: 999px;
  --shadow-sm: 0 1px 2px rgba(15, 40, 32, 0.05);
  --shadow-md: 0 8px 30px rgba(15, 40, 32, 0.08);
  --shadow-lg: 0 24px 60px rgba(15, 40, 32, 0.1);
  --max-width: 1140px;
  --header-height: 4.25rem;
}

*,
*::before,
*::after {
  box-sizing: border-box;
}

html {
  scroll-behavior: smooth;
}

@media (prefers-reduced-motion: reduce) {
  html {
    scroll-behavior: auto;
  }

  .news-ticker__inner,
  .hero-orb,
  .hero-scroll-hint__line {
    animation: none !important;
  }
}

body {
  margin: 0;
  min-height: 100vh;
  font-family: var(--font-body);
  font-size: 1.0625rem;
  line-height: 1.65;
  letter-spacing: 0.01em;
  color: var(--color-text);
  background-color: var(--color-bg);
  background-image:
    radial-gradient(ellipse 90% 60% at 0% 0%, rgba(11, 107, 88, 0.07), transparent 55%),
    radial-gradient(ellipse 70% 50% at 100% 10%, rgba(180, 200, 190, 0.35), transparent 50%),
    linear-gradient(180deg, #fbfcfb 0%, var(--color-bg) 38%, var(--color-bg) 100%);
}

img {
  max-width: 100%;
  height: auto;
}

.visually-hidden {
  position: absolute;
  width: 1px;
  height: 1px;
  padding: 0;
  margin: -1px;
  overflow: hidden;
  clip: rect(0, 0, 0, 0);
  white-space: nowrap;
  border: 0;
}

.skip-link {
  position: absolute;
  left: var(--space-md);
  top: -100px;
  z-index: 1000;
  padding: var(--space-sm) var(--space-md);
  background: var(--color-accent);
  color: #fff;
  font-weight: 600;
  border-radius: var(--radius);
  transition: top 0.2s;
}

.skip-link:focus {
  top: var(--space-md);
  outline: 2px solid var(--color-text);
  outline-offset: 2px;
}

/* Header */

.site-header {
  position: sticky;
  top: 0;
  z-index: 50;
  background: rgba(255, 255, 255, 0.88);
  backdrop-filter: blur(14px) saturate(1.2);
  border-bottom: 1px solid var(--color-border);
  box-shadow: var(--shadow-sm);
}

.site-header__inner {
  max-width: var(--max-width);
  margin: 0 auto;
  padding: var(--space-sm) var(--space-lg);
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: var(--space-md);
  min-height: var(--header-height);
}

.site-logo {
  display: inline-flex;
  align-items: center;
  text-decoration: none;
  color: var(--color-text);
  line-height: 0;
}

.site-logo__img {
  display: block;
  height: 3rem;
  width: auto;
  max-width: min(290px, 58vw);
  object-fit: contain;
}

@media (min-width: 480px) {
  .site-logo__img {
    height: 3.35rem;
    max-width: 320px;
  }
}

.site-nav {
  display: flex;
  align-items: center;
}

.nav-toggle {
  display: none;
  flex-direction: column;
  justify-content: center;
  gap: 5px;
  width: 2.75rem;
  height: 2.75rem;
  padding: 0;
  border: 1px solid var(--color-border);
  border-radius: var(--radius);
  background: var(--color-surface-elevated);
  cursor: pointer;
}

.nav-toggle:focus-visible {
  outline: 2px solid var(--color-accent);
  outline-offset: 2px;
}

.nav-toggle__bar {
  display: block;
  width: 1.25rem;
  height: 2px;
  margin: 0 auto;
  background: var(--color-text);
  border-radius: 1px;
}

.nav-list {
  display: flex;
  flex-wrap: wrap;
  align-items: center;
  gap: var(--space-xs) 0.95rem;
  list-style: none;
  margin: 0;
  padding: 0;
}

.nav-list__link {
  color: var(--color-text-muted);
  text-decoration: none;
  font-weight: 600;
  font-size: 0.9rem;
  padding: var(--space-xs) 0;
  border-bottom: 2px solid transparent;
  transition: color 0.15s, border-color 0.15s;
}

.nav-list__link:hover,
.nav-list__link:focus-visible {
  color: var(--color-text);
}

.nav-list__link.is-active {
  color: var(--color-text);
  border-bottom-color: var(--color-accent);
}

@media (max-width: 860px) {
  .nav-toggle {
    display: flex;
  }

  .nav-panel {
    position: fixed;
    inset: var(--header-height) 0 auto 0;
    background: #fff;
    border-bottom: 1px solid var(--color-border);
    padding: var(--space-md) var(--space-lg);
    transform: translateY(-100%);
    opacity: 0;
    visibility: hidden;
    transition: transform 0.2s, opacity 0.2s, visibility 0.2s;
    box-shadow: var(--shadow-lg);
  }

  .nav-panel.is-open {
    transform: translateY(0);
    opacity: 1;
    visibility: visible;
  }

  body.nav-open {
    overflow: hidden;
  }

  .nav-list {
    flex-direction: column;
    align-items: flex-start;
    gap: 0;
  }

  .nav-list__item {
    width: 100%;
    border-bottom: 1px solid var(--color-border);
  }

  .nav-list__link {
    display: block;
    padding: var(--space-md) 0;
  }
}

/* Main layout */

.site-main {
  max-width: var(--max-width);
  margin: 0 auto;
  padding: var(--space-xl) var(--space-lg) var(--space-2xl);
}

.page-header {
  margin-bottom: var(--space-xl);
}

.page-kicker {
  font-family: var(--font-body);
  font-size: 0.75rem;
  font-weight: 700;
  letter-spacing: 0.14em;
  text-transform: uppercase;
  color: var(--color-accent-muted);
  margin: 0 0 var(--space-sm);
}

.page-title {
  font-family: var(--font-display);
  font-size: clamp(2rem, 4vw, 2.75rem);
  font-weight: 600;
  line-height: 1.15;
  letter-spacing: -0.03em;
  margin: 0 0 var(--space-md);
}

.page-lead {
  font-size: 1.15rem;
  color: var(--color-text-muted);
  margin: 0;
}

/* Hero home */

.hero {
  padding: var(--space-lg) 0 var(--space-2xl);
}

/* Full-bleed hero band */

.hero--brand {
  margin: calc(-1 * var(--space-xl)) calc(-1 * var(--space-lg)) var(--space-xl);
  padding: clamp(2rem, 5vw, 3.5rem) var(--space-lg) var(--space-2xl);
  background:
    linear-gradient(165deg, #e9f3ee 0%, #f4faf7 38%, #ffffff 100%);
  border-bottom: 1px solid var(--color-border);
  border-radius: 0 0 clamp(20px, 4vw, 32px) clamp(20px, 4vw, 32px);
  box-shadow: inset 0 1px 0 rgba(255, 255, 255, 0.8);
  position: relative;
  overflow: hidden;
}

.hero--brand::before {
  content: "";
  position: absolute;
  inset: -40% -20% auto auto;
  width: min(70vw, 520px);
  height: min(70vw, 520px);
  background: radial-gradient(circle, rgba(11, 107, 88, 0.09) 0%, transparent 68%);
  pointer-events: none;
}

.hero--brand::after {
  content: "";
  position: absolute;
  inset: auto auto -30% -15%;
  width: min(55vw, 400px);
  height: min(55vw, 400px);
  background: radial-gradient(circle, rgba(100, 140, 120, 0.12) 0%, transparent 65%);
  pointer-events: none;
}

.hero--brand > * {
  position: relative;
  z-index: 1;
}

/* ================================================================
   PETRAGEN IMMERSIVE BLUE-BOX HERO
   ================================================================ */

.hero--petragen {
  position: relative;
  margin: calc(-1 * var(--space-xl)) calc(-1 * var(--space-lg)) var(--space-xl);
  padding: clamp(5rem, 10vw, 7.5rem) var(--space-lg) clamp(5rem, 10vw, 7rem);
  min-height: 92vh;
  text-align: center;
  color: #fff;
  border-bottom: none;
  border-radius: 0 0 clamp(20px, 4vw, 36px) clamp(20px, 4vw, 36px);
  overflow: hidden;
  isolation: isolate;
  display: flex;
  flex-direction: column;
  align-items: center;
  justify-content: center;
  background: url("/assets/img/hero-blueback.png") center 50% / cover no-repeat #041a2e;
}

/* Dark overlay so white text stays readable on the crystal image */
.hero--petragen::before {
  content: "";
  position: absolute;
  inset: 0;
  z-index: 0;
  background:
    radial-gradient(ellipse 80% 60% at 50% 40%, rgba(2, 12, 30, 0.35) 0%, transparent 70%),
    linear-gradient(180deg, rgba(2, 10, 25, 0.4) 0%, rgba(2, 10, 25, 0.55) 100%);
  pointer-events: none;
}

/* Subtle bottom vignette */
.hero--petragen::after {
  content: "";
  position: absolute;
  inset: 0;
  z-index: 1;
  background: linear-gradient(180deg, transparent 60%, rgba(2, 8, 20, 0.45) 100%);
  pointer-events: none;
}

/* Grid lines are now purely decorative, no image layer */
.hero--petragen .hero-grid-lines {
  background-image: none;
}

/* Floating luminous orbs */
.hero-orbs {
  position: absolute;
  inset: 0;
  z-index: 1;
  pointer-events: none;
  overflow: hidden;
}

.hero-orb {
  position: absolute;
  border-radius: 50%;
  filter: blur(1px);
  animation: hero-float 18s ease-in-out infinite;
}

.hero-orb--1 {
  width: 6px;
  height: 6px;
  background: rgba(100, 200, 255, 0.6);
  box-shadow: 0 0 14px 5px rgba(100, 200, 255, 0.3);
  top: 18%;
  left: 12%;
  animation-duration: 22s;
  animation-delay: -3s;
}

.hero-orb--2 {
  width: 4px;
  height: 4px;
  background: rgba(140, 210, 255, 0.5);
  box-shadow: 0 0 10px 3px rgba(140, 210, 255, 0.2);
  top: 32%;
  right: 18%;
  animation-duration: 16s;
  animation-delay: -7s;
}

.hero-orb--3 {
  width: 8px;
  height: 8px;
  background: rgba(80, 180, 240, 0.35);
  box-shadow: 0 0 22px 9px rgba(80, 180, 240, 0.15);
  bottom: 25%;
  left: 22%;
  animation-duration: 26s;
  animation-delay: -12s;
}

.hero-orb--4 {
  width: 5px;
  height: 5px;
  background: rgba(120, 200, 255, 0.45);
  box-shadow: 0 0 16px 6px rgba(120, 200, 255, 0.2);
  top: 55%;
  right: 10%;
  animation-duration: 20s;
  animation-delay: -5s;
}

.hero-orb--5 {
  width: 3px;
  height: 3px;
  background: rgba(160, 220, 255, 0.55);
  box-shadow: 0 0 8px 3px rgba(160, 220, 255, 0.25);
  top: 72%;
  left: 60%;
  animation-duration: 14s;
  animation-delay: -9s;
}

@keyframes hero-float {
  0%, 100% { transform: translate(0, 0) scale(1); opacity: 0.55; }
  25% { transform: translate(14px, -20px) scale(1.35); opacity: 1; }
  50% { transform: translate(-10px, -32px) scale(0.85); opacity: 0.45; }
  75% { transform: translate(18px, -12px) scale(1.2); opacity: 0.8; }
}

/* Grid overlay */
.hero-grid-lines {
  position: absolute;
  inset: 0;
  z-index: 0;
  opacity: 0.035;
  background-image:
    linear-gradient(rgba(255, 255, 255, 0.5) 1px, transparent 1px),
    linear-gradient(90deg, rgba(255, 255, 255, 0.5) 1px, transparent 1px);
  background-size: 80px 80px;
  pointer-events: none;
}

/* Scroll hint */
.hero-scroll-hint {
  position: absolute;
  bottom: 2.2rem;
  left: 50%;
  transform: translateX(-50%);
  z-index: 3;
}

.hero-scroll-hint__line {
  display: block;
  width: 1.5px;
  height: 42px;
  background: linear-gradient(180deg, rgba(255, 255, 255, 0.55), transparent);
  animation: hero-scroll-pulse 2.5s ease-in-out infinite;
}

@keyframes hero-scroll-pulse {
  0%, 100% { opacity: 0.25; transform: scaleY(0.55); transform-origin: top; }
  50% { opacity: 0.85; transform: scaleY(1); transform-origin: top; }
}

/* Hero inner */
.hero--petragen__inner {
  position: relative;
  z-index: 2;
  max-width: 46rem;
  margin: 0 auto;
  padding-top: clamp(0.5rem, 1.5vw, 1.2rem);
}

/* Badge pill */
.hero--petragen__badge {
  display: inline-flex;
  align-items: center;
  gap: 0.5rem;
  margin: 0 auto var(--space-xl);
  padding: 0.45rem 1.1rem 0.45rem 0.7rem;
  font-family: var(--font-body);
  font-size: 0.72rem;
  font-weight: 700;
  letter-spacing: 0.14em;
  text-transform: uppercase;
  color: rgba(255, 255, 255, 0.95);
  background: rgba(255, 255, 255, 0.08);
  border: 1px solid rgba(100, 200, 255, 0.25);
  border-radius: var(--radius-pill);
  backdrop-filter: blur(12px);
  box-shadow: 0 0 20px rgba(60, 160, 255, 0.08);
  animation: badge-glow 4s ease-in-out infinite alternate;
}

.hero--petragen__badge-icon {
  flex-shrink: 0;
  opacity: 0.95;
}

@keyframes badge-glow {
  0% { border-color: rgba(100, 200, 255, 0.2); box-shadow: 0 0 16px rgba(60, 160, 255, 0.06); }
  100% { border-color: rgba(100, 200, 255, 0.4); box-shadow: 0 0 28px rgba(60, 160, 255, 0.14); }
}

/* Hero title */
.hero--petragen__title {
  font-family: var(--font-body);
  font-size: clamp(2.1rem, 5vw, 3.25rem);
  font-weight: 700;
  line-height: 1.1;
  letter-spacing: -0.03em;
  margin: 0 0 var(--space-lg);
  color: #fff;
  text-shadow: 0 2px 30px rgba(0, 0, 0, 0.15);
}

/* Hero subhead */
.hero--petragen__lead {
  font-size: clamp(1rem, 2vw, 1.18rem);
  line-height: 1.72;
  color: rgba(255, 255, 255, 0.85);
  margin: 0 auto var(--space-xl);
  max-width: 36rem;
  font-weight: 400;
}

/* Proof strip with dots */
.hero-proof-strip {
  display: flex;
  flex-wrap: wrap;
  justify-content: center;
  gap: var(--space-md) var(--space-lg);
  margin: 0 auto var(--space-lg);
  max-width: 48rem;
}

.hero-proof-strip__item {
  display: inline-flex;
  align-items: center;
  gap: 0.5rem;
  font-size: 0.9rem;
  font-weight: 600;
  color: rgba(255, 255, 255, 0.9);
}

.hero-proof-strip__dot {
  width: 6px;
  height: 6px;
  border-radius: 50%;
  background: rgba(100, 200, 255, 0.8);
  box-shadow: 0 0 8px rgba(100, 200, 255, 0.4);
  flex-shrink: 0;
}

/* Stat band */
.hero-stat-band {
  display: flex;
  flex-wrap: wrap;
  justify-content: center;
  align-items: center;
  gap: var(--space-lg);
  margin: 0 auto var(--space-xl);
  padding: var(--space-md) var(--space-lg);
  max-width: 44rem;
  background: rgba(255, 255, 255, 0.06);
  border: 1px solid rgba(255, 255, 255, 0.12);
  border-radius: var(--radius);
  backdrop-filter: blur(10px);
}

.hero-stat {
  display: flex;
  flex-direction: column;
  align-items: center;
  gap: 0.15rem;
}

.hero-stat__number {
  font-size: 1.6rem;
  font-weight: 700;
  color: rgba(140, 215, 255, 1);
  letter-spacing: -0.02em;
  line-height: 1.1;
  text-shadow: 0 0 20px rgba(100, 200, 255, 0.3);
}

.hero-stat__label {
  font-size: 0.75rem;
  font-weight: 500;
  color: rgba(255, 255, 255, 0.65);
  text-transform: uppercase;
  letter-spacing: 0.06em;
}

.hero-stat-band__divider {
  width: 1px;
  height: 2.2rem;
  background: rgba(255, 255, 255, 0.15);
}

@media (max-width: 580px) {
  .hero-stat-band {
    gap: var(--space-md);
    padding: var(--space-sm) var(--space-md);
  }

  .hero-stat-band__divider {
    display: none;
  }

  .hero-stat {
    min-width: 40%;
  }
}

/* Hero opportunity band (legacy fallback) */
.hero-opportunity-band {
  margin: 0 auto var(--space-lg);
  max-width: 42rem;
  padding: 0.55rem 0.85rem;
  border-radius: var(--radius-pill);
  font-size: 0.8rem;
  font-weight: 600;
  color: rgba(255, 255, 255, 0.92);
  background: rgba(255, 255, 255, 0.1);
  border: 1px solid rgba(255, 255, 255, 0.24);
}

/* Hero actions */
.hero--petragen__actions {
  display: flex;
  flex-wrap: wrap;
  gap: var(--space-md);
  justify-content: center;
  align-items: center;
  margin-bottom: var(--space-md);
}

.btn__arrow {
  margin-left: 0.15em;
}

.btn--hero-primary {
  background: #fff !important;
  color: var(--color-accent) !important;
  border: none !important;
  box-shadow: 0 8px 32px rgba(0, 0, 0, 0.22), 0 0 0 1px rgba(255, 255, 255, 0.1);
  font-weight: 700;
  padding: 0.75rem 1.75rem;
  font-size: 1.05rem;
  transition: background 0.2s, transform 0.2s, box-shadow 0.2s;
}

.btn--hero-primary:hover {
  background: #f0faf7 !important;
  color: var(--color-accent-hover) !important;
  filter: none;
  transform: translateY(-1px);
  box-shadow: 0 12px 40px rgba(0, 0, 0, 0.28), 0 0 0 1px rgba(255, 255, 255, 0.15);
}

.btn--hero-ghost {
  background: rgba(255, 255, 255, 0.06) !important;
  color: #fff !important;
  border: 1.5px solid rgba(255, 255, 255, 0.35) !important;
  font-weight: 600;
  padding: 0.75rem 1.75rem;
  font-size: 1.05rem;
  backdrop-filter: blur(6px);
  transition: background 0.2s, border-color 0.2s, transform 0.2s;
}

.btn--hero-ghost:hover {
  background: rgba(255, 255, 255, 0.14) !important;
  border-color: rgba(255, 255, 255, 0.6) !important;
  color: #fff !important;
  transform: translateY(-1px);
}

/* ================================================================
   SECTION DIVIDER (gradient accent line between major sections)
   ================================================================ */

.home-biology,
.home-pillars,
.home-lead-program,
.home-opportunity,
.section {
  position: relative;
}

/* ================================================================
   HOME BIOLOGY SECTION
   ================================================================ */

.home-biology {
  margin: var(--space-xl) calc(-1 * var(--space-lg));
  padding: var(--space-2xl) var(--space-lg);
  background:
    radial-gradient(ellipse 60% 50% at 80% 20%, rgba(11, 107, 88, 0.04), transparent 60%),
    linear-gradient(180deg, #f0f8f4 0%, #f6faf7 50%, var(--color-bg) 100%);
  border-top: 1px solid var(--color-border);
  border-bottom: 1px solid var(--color-border);
}

.home-biology__inner {
  max-width: 54rem;
  margin: 0 auto;
  text-align: center;
}

.home-biology__title {
  font-family: var(--font-display);
  font-size: clamp(1.5rem, 3vw, 1.9rem);
  font-weight: 600;
  margin: 0 0 var(--space-md);
  color: var(--color-text);
}

.home-biology__lead {
  margin: 0 0 var(--space-xl);
  font-size: 1.08rem;
  color: var(--color-text-muted);
  line-height: 1.65;
  max-width: 48rem;
  margin-left: auto;
  margin-right: auto;
}

.home-biology__bullets {
  list-style: none;
  margin: 0;
  padding: 0;
  display: grid;
  grid-template-columns: 1fr;
  gap: var(--space-md);
  max-width: 38rem;
  margin: 0 auto;
  text-align: left;
}

@media (min-width: 640px) {
  .home-biology__bullets {
    max-width: 48rem;
  }
}

.home-biology__bullets li {
  position: relative;
  padding-left: 1.75rem;
  color: var(--color-text-muted);
  font-size: 0.97rem;
  line-height: 1.6;
}

.home-biology__bullets li::before {
  content: "";
  position: absolute;
  left: 0;
  top: 0.55rem;
  width: 8px;
  height: 8px;
  background: var(--color-accent);
  border-radius: 50%;
  box-shadow: 0 0 6px rgba(11, 107, 88, 0.3);
}

/* ================================================================
   HOME LEAD PROGRAM SECTION
   ================================================================ */

.home-lead-program {
  margin: var(--space-xl) 0;
  padding: var(--space-xl) var(--space-lg);
  background: var(--color-surface);
  border: 1px solid var(--color-border);
  border-radius: var(--radius);
  box-shadow: var(--shadow-sm);
  position: relative;
  overflow: hidden;
}

.home-lead-program::before {
  content: "";
  position: absolute;
  top: 0;
  left: 0;
  right: 0;
  height: 3px;
  background: linear-gradient(90deg, var(--color-accent), #3aa892, rgba(11, 107, 88, 0.3));
  border-radius: var(--radius) var(--radius) 0 0;
}

.home-lead-program__inner {
  max-width: 54rem;
  margin: 0 auto;
}

.home-lead-program__title {
  font-family: var(--font-display);
  font-size: clamp(1.4rem, 2.5vw, 1.75rem);
  font-weight: 600;
  margin: 0 0 var(--space-md);
  color: var(--color-accent);
}

.home-lead-program__lead {
  margin: 0 0 var(--space-lg);
  font-size: 1.05rem;
  color: var(--color-text-muted);
  line-height: 1.65;
}

.home-lead-program__bullets {
  list-style: none;
  margin: 0;
  padding: 0;
}

.home-lead-program__bullets li {
  position: relative;
  padding-left: 1.75rem;
  margin-bottom: var(--space-sm);
  color: var(--color-text);
  font-weight: 500;
}

.home-lead-program__bullets li::before {
  content: "";
  position: absolute;
  left: 0;
  top: 0.55rem;
  width: 8px;
  height: 8px;
  background: var(--color-accent);
  border-radius: 50%;
  box-shadow: 0 0 6px rgba(11, 107, 88, 0.3);
}

/* ================================================================
   HOME OPPORTUNITY SECTION
   ================================================================ */

.home-opportunity {
  margin: var(--space-2xl) 0;
}

.home-opportunity__header {
  text-align: center;
  max-width: 44rem;
  margin: 0 auto var(--space-xl);
}

.home-opportunity__title {
  font-family: var(--font-display);
  font-size: clamp(1.5rem, 3vw, 2rem);
  font-weight: 600;
  margin: 0 0 var(--space-sm);
  color: var(--color-text);
}

.home-opportunity__lead {
  margin: 0;
  font-size: 1.05rem;
  color: var(--color-text-muted);
  line-height: 1.55;
}

.program-card-grid {
  display: grid;
  gap: var(--space-lg);
  grid-template-columns: repeat(auto-fill, minmax(240px, 1fr));
}

.program-card {
  background: var(--color-surface);
  border: 1px solid var(--color-border);
  border-radius: var(--radius);
  padding: var(--space-lg);
  box-shadow: var(--shadow-sm);
  transition: border-color 0.2s, box-shadow 0.2s, transform 0.25s;
  position: relative;
  overflow: hidden;
}

.program-card::before {
  content: "";
  position: absolute;
  top: 0;
  left: 0;
  right: 0;
  height: 3px;
  background: linear-gradient(90deg, transparent, var(--color-accent), transparent);
  opacity: 0;
  transition: opacity 0.3s;
}

.program-card:hover {
  border-color: rgba(11, 107, 88, 0.3);
  box-shadow: var(--shadow-md);
  transform: translateY(-3px);
}

.program-card:hover::before {
  opacity: 1;
}

.program-card__title {
  font-family: var(--font-display);
  font-size: 1.15rem;
  font-weight: 600;
  margin: 0 0 var(--space-sm);
  color: var(--color-text);
}

.program-card__body {
  margin: 0;
  font-size: 0.95rem;
  line-height: 1.55;
  color: var(--color-text-muted);
}

/* ================================================================
   HOME PILLARS (three-card proof strip)
   ================================================================ */

.home-pillars {
  margin-bottom: var(--space-2xl);
  padding-top: var(--space-md);
  padding-bottom: var(--space-sm);
}

.home-pillars--compact {
  margin-top: var(--space-xl);
  margin-bottom: var(--space-xl);
}

.home-pillars__header {
  text-align: center;
  max-width: 40rem;
  margin: 0 auto var(--space-xl);
}

.home-pillars__title {
  font-family: var(--font-display);
  font-size: clamp(1.6rem, 3vw, 2rem);
  font-weight: 600;
  margin: 0 0 var(--space-sm);
}

.home-pillars__subtitle {
  margin: 0;
  font-size: 1.05rem;
  color: var(--color-text-muted);
  line-height: 1.55;
}

.pillar-grid {
  display: grid;
  gap: var(--space-lg);
  grid-template-columns: 1fr;
}

@media (min-width: 768px) {
  .pillar-grid {
    grid-template-columns: repeat(3, 1fr);
  }
}

.pillar-card {
  background: var(--color-surface);
  border: 1px solid var(--color-border);
  border-radius: var(--radius);
  padding: var(--space-lg);
  box-shadow: var(--shadow-sm);
  transition: box-shadow 0.25s, transform 0.25s, border-color 0.25s;
  position: relative;
  overflow: hidden;
}

.pillar-card::before {
  content: "";
  position: absolute;
  top: 0;
  left: 0;
  right: 0;
  height: 3px;
  background: linear-gradient(90deg, var(--color-accent), #3aa892);
  opacity: 0;
  transition: opacity 0.3s;
}

.pillar-card:hover {
  box-shadow: var(--shadow-md);
  transform: translateY(-3px);
  border-color: rgba(11, 107, 88, 0.2);
}

.pillar-card:hover::before {
  opacity: 1;
}

.pillar-card__title {
  font-family: var(--font-display);
  font-size: 1.2rem;
  font-weight: 600;
  margin: 0 0 var(--space-sm);
  color: var(--color-text);
}

.pillar-card__body {
  margin: 0;
  font-size: 0.98rem;
  line-height: 1.6;
  color: var(--color-text-muted);
}

/* ================================================================
   CTA BAND
   ================================================================ */

.cta-band {
  margin: 0 calc(-1 * var(--space-lg)) calc(-1 * var(--space-2xl));
  padding: clamp(3rem, 6vw, 4.5rem) var(--space-lg);
  background:
    radial-gradient(ellipse 80% 60% at 30% 40%, rgba(60, 200, 160, 0.12), transparent 55%),
    linear-gradient(135deg, #0a5a4a 0%, var(--color-accent) 50%, #064d40 100%);
  color: #f0faf7;
  text-align: center;
  position: relative;
  overflow: hidden;
}

.cta-band::before {
  content: "";
  position: absolute;
  inset: 0;
  opacity: 0.04;
  background-image:
    linear-gradient(rgba(255, 255, 255, 0.5) 1px, transparent 1px),
    linear-gradient(90deg, rgba(255, 255, 255, 0.5) 1px, transparent 1px);
  background-size: 50px 50px;
  pointer-events: none;
}

.cta-band__inner {
  max-width: 38rem;
  margin: 0 auto;
  position: relative;
  z-index: 1;
}

.cta-band__title {
  font-family: var(--font-display);
  font-size: clamp(1.45rem, 3vw, 1.85rem);
  font-weight: 600;
  margin: 0 0 var(--space-md);
  color: #fff;
}

.cta-band__text {
  margin: 0 0 var(--space-lg);
  font-size: 1.05rem;
  line-height: 1.65;
  opacity: 0.95;
}

.btn--on-dark {
  background: #fff;
  color: var(--color-accent-hover);
  border-color: transparent;
  box-shadow: 0 4px 20px rgba(0, 0, 0, 0.12);
  transition: background 0.2s, transform 0.2s, box-shadow 0.2s;
}

.btn--on-dark:hover {
  background: #f0faf7;
  color: var(--color-accent-hover);
  transform: translateY(-1px);
  box-shadow: 0 6px 28px rgba(0, 0, 0, 0.18);
}

/* ================================================================
   LEGACY HERO GRID
   ================================================================ */

.hero__grid {
  display: grid;
  gap: var(--space-xl);
  align-items: start;
}

@media (min-width: 900px) {
  .hero__grid {
    grid-template-columns: 1.1fr 0.9fr;
  }
}

.hero__title {
  font-family: var(--font-display);
  font-size: clamp(2.25rem, 4.5vw, 3.25rem);
  font-weight: 600;
  line-height: 1.12;
  letter-spacing: -0.03em;
  margin: 0 0 var(--space-md);
}

.hero__sub {
  font-size: 1.2rem;
  color: var(--color-text-muted);
  margin: 0 0 var(--space-lg);
  max-width: 52ch;
}

.hero__card {
  background: var(--color-surface);
  border: 1px solid var(--color-border);
  border-radius: var(--radius);
  padding: var(--space-lg);
  box-shadow: var(--shadow-md);
}

.hero__card-title {
  font-family: var(--font-display);
  font-size: 1.25rem;
  margin: 0 0 var(--space-sm);
}

.hero__card-body {
  margin: 0;
  color: var(--color-text-muted);
  font-size: 1rem;
}

.hero__actions {
  display: flex;
  flex-wrap: wrap;
  gap: var(--space-sm);
  margin-top: var(--space-lg);
}

/* ================================================================
   NEWS TICKER
   ================================================================ */

.news-ticker {
  margin-bottom: var(--space-xl);
  border-radius: var(--radius-pill);
  border: 1px solid rgba(138, 90, 28, 0.15);
  background: linear-gradient(90deg, #fff9ed 0%, #fff4e0 100%);
  overflow: hidden;
  box-shadow: var(--shadow-sm);
}

.news-ticker__track {
  padding: var(--space-sm) var(--space-md);
  display: flex;
  flex-wrap: wrap;
  align-items: center;
  gap: var(--space-md);
}

.news-ticker__track--static .news-ticker__text {
  flex: 1;
  min-width: min(100%, 240px);
}

.news-ticker__inner {
  display: inline-block;
  white-space: nowrap;
  animation: ticker-scroll 28s linear infinite;
}

@keyframes ticker-scroll {
  0% {
    transform: translateX(0);
  }

  100% {
    transform: translateX(-50%);
  }
}

.news-ticker__text {
  font-size: 0.9rem;
  font-weight: 600;
  color: var(--color-warm);
}

.news-ticker__link {
  color: var(--color-accent);
  font-weight: 700;
  text-decoration: none;
  white-space: nowrap;
}

.news-ticker__link:hover {
  text-decoration: underline;
  text-underline-offset: 3px;
}

/* ================================================================
   BUTTONS
   ================================================================ */

.btn {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  padding: 0.65rem 1.35rem;
  font-family: var(--font-body);
  font-size: 1rem;
  font-weight: 600;
  text-decoration: none;
  border-radius: var(--radius-pill);
  border: 2px solid transparent;
  cursor: pointer;
  transition: background 0.15s, color 0.15s, border-color 0.15s, transform 0.15s;
}

.btn:focus-visible {
  outline: 2px solid var(--color-accent);
  outline-offset: 3px;
}

.btn--primary {
  background: var(--color-accent);
  color: #fff;
  box-shadow: 0 4px 14px rgba(11, 107, 88, 0.25);
}

.btn--primary:hover {
  background: var(--color-accent-hover);
  box-shadow: 0 6px 20px rgba(11, 107, 88, 0.3);
  transform: translateY(-1px);
}

.btn--ghost {
  background: #fff;
  color: var(--color-text);
  border-color: rgba(20, 48, 40, 0.18);
}

.btn--ghost:hover {
  border-color: var(--color-accent);
  color: var(--color-accent);
}

.btn--secondary {
  background: var(--color-surface-elevated);
  color: var(--color-text);
  border-color: var(--color-border);
}

/* ================================================================
   GENERIC SECTIONS
   ================================================================ */

.section {
  margin-bottom: var(--space-2xl);
}

.section-header {
  margin-bottom: var(--space-xl);
  max-width: none;
}

.section-header__lead {
  margin: 0;
  max-width: none;
  color: var(--color-text-muted);
  font-size: 1.05rem;
  line-height: 1.65;
}

.section__title {
  font-family: var(--font-display);
  font-size: 1.65rem;
  margin: 0 0 var(--space-md);
}

.prose {
  max-width: 68ch;
}

.prose p {
  margin: 0 0 var(--space-md);
  color: var(--color-text-muted);
}

.prose p:last-child {
  margin-bottom: 0;
}

.two-col {
  display: grid;
  gap: var(--space-lg);
}

@media (min-width: 768px) {
  .two-col {
    grid-template-columns: 1fr 1fr;
  }
}

/* ================================================================
   LISTS
   ================================================================ */

.link-list {
  list-style: none;
  margin: 0;
  padding: 0;
}

.link-list li {
  border-bottom: 1px solid var(--color-border);
  padding: var(--space-md) 0;
}

.link-list a {
  color: var(--color-text);
  font-weight: 600;
  text-decoration: none;
}

.link-list a:hover {
  text-decoration: underline;
  text-underline-offset: 3px;
}

.link-list__meta {
  display: block;
  font-size: 0.9rem;
  color: var(--color-text-muted);
  font-weight: 400;
  margin-top: var(--space-xs);
}

.link-list__authors {
  display: block;
  font-size: 0.85rem;
  color: var(--color-text-muted);
  margin-top: 0.25rem;
  line-height: 1.45;
}

.pub-title {
  font-weight: 600;
  color: var(--color-text);
}

.pub-significance {
  display: block;
  font-size: 0.85rem;
  color: var(--color-accent);
  margin-top: 0.35rem;
  font-style: italic;
  line-height: 1.45;
}

.link-list--publications li {
  padding: var(--space-md) 0;
  border-bottom: 1px solid var(--color-border);
}

/* ================================================================
   SCIENCE DIAGRAM
   ================================================================ */

.diagram {
  margin: var(--space-lg) 0;
  padding: var(--space-lg);
  background: linear-gradient(180deg, #fafcfb 0%, #fff 100%);
  border: 1px solid var(--color-border);
  border-radius: var(--radius);
  box-shadow: var(--shadow-sm);
}

.diagram svg,
.diagram img {
  display: block;
  width: 100%;
  max-height: 420px;
  object-fit: contain;
  border-radius: 8px;
}

.diagram--wide img {
  max-height: 320px;
}

.diagram__caption {
  margin: var(--space-md) 0 0;
  font-size: 0.88rem;
  color: var(--color-text-muted);
  line-height: 1.5;
  text-align: center;
}

.diagram--mechanism {
  margin: var(--space-lg) 0;
  padding: var(--space-md);
  background: linear-gradient(180deg, #fefefe 0%, #f8faf9 100%);
}

.diagram--mechanism img {
  max-height: 280px;
}

.diagram-pair {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: var(--space-lg);
  margin: var(--space-lg) 0;
}

.diagram--paired {
  margin: 0;
  padding: var(--space-md);
}

.diagram--paired img {
  max-height: 300px;
}

@media (max-width: 768px) {
  .diagram-pair {
    grid-template-columns: 1fr;
  }
}

/* ================================================================
   PIPELINE CHART
   ================================================================ */

.pipeline-chart {
  margin: var(--space-xl) 0;
}

.pipeline-chart__title {
  font-size: 1rem;
  font-weight: 700;
  margin: 0 0 var(--space-md);
}

.pipeline-bars {
  display: flex;
  flex-direction: column;
  gap: var(--space-sm);
}

.pipeline-bar {
  display: grid;
  grid-template-columns: minmax(100px, 140px) 1fr;
  gap: var(--space-md);
  align-items: center;
}

@media (max-width: 520px) {
  .pipeline-bar {
    grid-template-columns: 1fr;
    gap: var(--space-xs);
  }
}

.pipeline-bar__label {
  font-size: 0.9rem;
  font-weight: 600;
  color: var(--color-text-muted);
}

.pipeline-bar__track {
  height: 0.65rem;
  background: #e4ebe7;
  border-radius: var(--radius-pill);
  overflow: hidden;
  border: 1px solid rgba(20, 48, 40, 0.08);
}

.pipeline-bar__fill {
  height: 100%;
  border-radius: var(--radius-pill);
  background: linear-gradient(90deg, var(--color-accent), #3aa892);
}

/* ================================================================
   PIPELINE FILTERS + CARDS
   ================================================================ */

.pipeline-tools {
  margin-bottom: var(--space-lg);
}

.filter-chips {
  display: flex;
  flex-wrap: wrap;
  gap: var(--space-sm);
  margin: var(--space-md) 0 0;
  padding: 0;
  list-style: none;
}

.filter-chips__btn {
  font-family: var(--font-body);
  font-size: 0.9rem;
  font-weight: 600;
  padding: 0.45rem 1rem;
  border-radius: var(--radius-pill);
  border: 1px solid rgba(20, 48, 40, 0.12);
  background: #fff;
  color: var(--color-text-muted);
  cursor: pointer;
  transition: background 0.15s, color 0.15s, border-color 0.15s;
}

.filter-chips__btn:hover {
  color: var(--color-text);
  border-color: var(--color-accent);
}

.filter-chips__btn[aria-pressed="true"] {
  background: var(--color-accent-soft);
  border-color: var(--color-accent);
  color: var(--color-text);
}

.filter-chips__btn:focus-visible {
  outline: 2px solid var(--color-accent);
  outline-offset: 2px;
}

.card-grid {
  display: grid;
  grid-template-columns: repeat(auto-fill, minmax(260px, 1fr));
  gap: var(--space-md);
}

.card-grid--disease {
  gap: var(--space-lg);
  grid-template-columns: repeat(auto-fill, minmax(280px, 1fr));
}

.disease-card {
  background: var(--color-surface);
  border: 1px solid var(--color-border);
  border-radius: var(--radius);
  padding: 0;
  box-shadow: var(--shadow-sm);
  display: flex;
  flex-direction: column;
  min-height: 100%;
  transition: border-color 0.2s, box-shadow 0.25s, transform 0.25s;
  overflow: hidden;
  position: relative;
}

.disease-card::before {
  content: "";
  position: absolute;
  top: 0;
  left: 0;
  right: 0;
  height: 3px;
  background: linear-gradient(90deg, var(--color-accent), #3aa892, transparent);
  opacity: 0;
  transition: opacity 0.3s;
  z-index: 1;
}

.disease-card:hover {
  border-color: rgba(11, 107, 88, 0.25);
  box-shadow: var(--shadow-md);
  transform: translateY(-3px);
}

.disease-card:hover::before {
  opacity: 1;
}

.disease-card__img-wrap {
  width: 100%;
  aspect-ratio: 16 / 9;
  overflow: hidden;
  background: linear-gradient(135deg, #f0f6f3 0%, #e8f0ec 100%);
}

.disease-card__img {
  width: 100%;
  height: 100%;
  object-fit: cover;
  transition: transform 0.4s ease;
}

.disease-card:hover .disease-card__img {
  transform: scale(1.04);
}

.disease-card__title {
  margin: 0 0 var(--space-sm);
  padding: var(--space-lg) var(--space-lg) 0;
  font-family: var(--font-display);
  font-size: 1.25rem;
}

.disease-card__summary {
  margin: 0 0 var(--space-md);
  padding: 0 var(--space-lg);
  color: var(--color-text-muted);
  font-size: 0.95rem;
  line-height: 1.55;
  flex: 1;
}

.disease-card__link {
  display: inline-block;
  padding: 0 var(--space-lg) var(--space-lg);
  color: var(--color-accent);
  text-decoration: none;
  font-weight: 700;
  font-size: 0.95rem;
  transition: color 0.15s;
}

.disease-card__link:hover {
  color: var(--color-accent-hover);
  text-decoration: underline;
  text-underline-offset: 3px;
}

.card-grid--leaders {
  grid-template-columns: repeat(auto-fill, minmax(300px, 1fr));
}

.leader-teaser {
  background: var(--color-surface);
  border: 1px solid var(--color-border);
  border-radius: var(--radius);
  overflow: hidden;
  box-shadow: var(--shadow-sm);
  transition: box-shadow 0.25s, transform 0.25s;
  position: relative;
}

.leader-teaser::before {
  content: "";
  position: absolute;
  top: 0;
  left: 0;
  right: 0;
  height: 3px;
  background: linear-gradient(90deg, var(--color-accent), #3aa892, transparent);
  opacity: 0;
  transition: opacity 0.3s;
  z-index: 1;
}

.leader-teaser:hover {
  box-shadow: var(--shadow-md);
  transform: translateY(-3px);
}

.leader-teaser:hover::before {
  opacity: 1;
}

.leader-teaser__img {
  width: 100%;
  height: 260px;
  object-fit: cover;
  object-position: center top;
  display: block;
  transition: transform 0.4s ease;
}

.leader-teaser:hover .leader-teaser__img {
  transform: scale(1.03);
}

.leader-teaser__body {
  padding: var(--space-md);
}

.leader-teaser__tag {
  margin: 0 0 var(--space-xs);
  color: var(--color-accent);
  font-size: 0.75rem;
  font-weight: 700;
  letter-spacing: 0.1em;
  text-transform: uppercase;
}

.leader-teaser__name {
  margin: 0 0 0.35rem;
  font-size: 1.12rem;
}

.leader-teaser__role {
  margin: 0;
  color: var(--color-text-muted);
  font-size: 0.95rem;
}

.section-footer-link {
  margin: var(--space-md) 0 0;
}

.section-footer-link a {
  color: var(--color-accent);
  text-decoration: none;
  font-weight: 700;
}

.section-footer-link a:hover {
  text-decoration: underline;
}

/* ================================================================
   PIPELINE INDICATION CARDS
   ================================================================ */

.pipeline-card {
  background: var(--color-surface);
  border: 1px solid var(--color-border);
  border-radius: var(--radius);
  padding: var(--space-lg);
  display: flex;
  flex-direction: column;
  min-height: 100%;
  transition: border-color 0.2s, box-shadow 0.2s, transform 0.25s;
}

.pipeline-card:hover {
  border-color: rgba(11, 107, 88, 0.35);
  box-shadow: var(--shadow-md);
  transform: translateY(-3px);
}

.pipeline-card.is-hidden {
  display: none;
}

.pipeline-card__badge {
  align-self: flex-start;
  font-family: var(--font-body);
  font-size: 0.68rem;
  font-weight: 700;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  padding: 0.3rem 0.65rem;
  border-radius: var(--radius-pill);
  background: var(--color-accent-soft);
  color: var(--color-accent-hover);
  margin-bottom: var(--space-sm);
  border: 1px solid rgba(11, 107, 88, 0.12);
}

.pipeline-card__name {
  font-family: var(--font-display);
  font-size: 1.25rem;
  margin: 0 0 var(--space-xs);
}

.pipeline-card__indication {
  font-size: 0.85rem;
  color: var(--color-accent-muted);
  font-weight: 600;
  margin: 0 0 var(--space-sm);
}

.pipeline-card__summary {
  margin: 0;
  font-size: 0.95rem;
  color: var(--color-text-muted);
  flex: 1;
}

/* ================================================================
   TEAM
   ================================================================ */

.team-tier {
  margin-bottom: var(--space-xl);
}

.team-tier__title {
  font-family: var(--font-display);
  font-size: 1.35rem;
  margin: 0 0 var(--space-lg);
  padding-bottom: var(--space-sm);
  border-bottom: 1px solid var(--color-border);
}

.team-grid {
  display: grid;
  grid-template-columns: repeat(auto-fill, minmax(260px, 1fr));
  gap: var(--space-lg);
}

.team-card {
  background: var(--color-surface);
  border: 1px solid var(--color-border);
  border-radius: var(--radius);
  padding: var(--space-md);
  display: grid;
  grid-template-columns: 105px 1fr;
  gap: var(--space-md);
  box-shadow: var(--shadow-sm);
  transition: box-shadow 0.25s, transform 0.25s;
}

.team-card:hover {
  box-shadow: var(--shadow-md);
  transform: translateY(-2px);
}

@media (max-width: 580px) {
  .team-card {
    grid-template-columns: 1fr;
  }
}

.team-card__avatar {
  width: 5rem;
  height: 5rem;
  border-radius: 50%;
  background: linear-gradient(145deg, #0d7a64, var(--color-accent));
  display: flex;
  align-items: center;
  justify-content: center;
  font-weight: 700;
  font-size: 0.95rem;
  color: #fff;
  box-shadow: 0 4px 12px rgba(11, 107, 88, 0.22);
}

.team-card__photo {
  width: 100%;
  height: 118px;
  border-radius: 12px;
  object-fit: cover;
  border: 1px solid var(--color-border);
}

.team-card__body {
  min-width: 0;
}

.team-card__tag {
  margin: 0 0 0.35rem;
  color: var(--color-accent);
  font-size: 0.72rem;
  font-weight: 700;
  letter-spacing: 0.1em;
  text-transform: uppercase;
}

.team-card__name {
  font-weight: 700;
  margin: 0 0 var(--space-xs);
  font-size: 1.05rem;
}

.team-card__role {
  font-size: 0.85rem;
  color: var(--color-accent);
  font-weight: 600;
  margin: 0 0 var(--space-sm);
}

.team-card__bio {
  margin: 0;
  font-size: 0.95rem;
  color: var(--color-text-muted);
}

.team-card__credentials {
  margin: var(--space-sm) 0 0;
  padding: 0 0 0 1rem;
  color: var(--color-text-muted);
  font-size: 0.9rem;
}

.team-card__credentials li {
  margin-bottom: 0.35rem;
}

/* ================================================================
   ABOUT PAGE
   ================================================================ */

.about-section {
  margin-bottom: var(--space-xl);
}

.about-section__headline {
  font-family: var(--font-display);
  font-size: 1.4rem;
  font-weight: 600;
  margin: 0 0 var(--space-sm);
  color: var(--color-text);
}

.about-section__body {
  margin: 0;
  font-size: 1.05rem;
  line-height: 1.65;
  color: var(--color-text-muted);
}

.about-team-teaser {
  margin-top: var(--space-2xl);
}

/* ================================================================
   TIMELINE
   ================================================================ */

.timeline {
  border-left: 2px solid var(--color-border);
  margin: var(--space-lg) 0;
  padding-left: var(--space-lg);
}

.timeline__item {
  position: relative;
  margin-bottom: var(--space-lg);
}

.timeline__item::before {
  content: "";
  position: absolute;
  left: calc(-1 * var(--space-lg) - 6px);
  top: 0.35rem;
  width: 10px;
  height: 10px;
  border-radius: 50%;
  background: var(--color-accent);
  box-shadow: 0 0 0 4px var(--color-surface);
}

.timeline__year {
  font-weight: 700;
  color: var(--color-accent);
  margin: 0 0 var(--space-xs);
}

.timeline__text {
  margin: 0;
  color: var(--color-text-muted);
}

/* ================================================================
   FORMS
   ================================================================ */

.form {
  max-width: 520px;
}

.form__row {
  margin-bottom: var(--space-md);
}

.form label {
  display: block;
  font-weight: 600;
  margin-bottom: var(--space-xs);
}

.input,
select,
textarea {
  font-family: var(--font-body);
  font-size: 1rem;
  width: 100%;
  padding: 0.65rem 0.85rem;
  border-radius: 10px;
  border: 1px solid rgba(20, 48, 40, 0.14);
  background: #fff;
  color: var(--color-text);
  transition: border-color 0.2s, box-shadow 0.2s;
}

.input:focus-visible,
select:focus-visible,
textarea:focus-visible {
  outline: none;
  border-color: var(--color-accent);
  box-shadow: 0 0 0 3px rgba(11, 107, 88, 0.12);
}

textarea {
  min-height: 140px;
  resize: vertical;
}

.form__error {
  color: #b42318;
  font-size: 0.9rem;
  margin: var(--space-sm) 0 0;
}

.alert {
  padding: var(--space-md);
  border-radius: var(--radius);
  margin-bottom: var(--space-lg);
}

.alert--success {
  background: #e8f5f1;
  border: 1px solid rgba(11, 107, 88, 0.28);
  color: var(--color-text);
}

.alert--error {
  background: #fef2f2;
  border: 1px solid rgba(180, 60, 60, 0.35);
  color: var(--color-text);
}

.honeypot {
  position: absolute;
  left: -9999px;
  width: 1px;
  height: 1px;
  opacity: 0;
}

/* ================================================================
   CAREERS
   ================================================================ */

.careers-values {
  margin-bottom: var(--space-xl);
}

.careers-bullets {
  list-style: none;
  margin: 0;
  padding: 0;
  display: flex;
  flex-wrap: wrap;
  gap: var(--space-md);
}

.careers-bullets li {
  position: relative;
  padding: var(--space-md) var(--space-lg);
  background: var(--color-surface);
  border: 1px solid var(--color-border);
  border-radius: var(--radius);
  font-weight: 600;
  color: var(--color-text);
  box-shadow: var(--shadow-sm);
  transition: box-shadow 0.25s, transform 0.25s;
}

.careers-bullets li:hover {
  box-shadow: var(--shadow-md);
  transform: translateY(-2px);
}

.careers-bullets li::before {
  content: "";
  display: inline-block;
  width: 8px;
  height: 8px;
  margin-right: 0.5rem;
  background: var(--color-accent);
  border-radius: 50%;
  vertical-align: middle;
  box-shadow: 0 0 6px rgba(11, 107, 88, 0.3);
}

.job-list {
  list-style: none;
  margin: 0;
  padding: 0;
}

.job-list li {
  border-bottom: 1px solid var(--color-border);
}

.job-list a {
  display: flex;
  flex-wrap: wrap;
  justify-content: space-between;
  gap: var(--space-sm);
  padding: var(--space-md) 0;
  color: var(--color-text);
  text-decoration: none;
  font-weight: 600;
}

.job-list a:hover .job-list__title {
  text-decoration: underline;
}

.job-list__loc {
  font-weight: 400;
  color: var(--color-text-muted);
  font-size: 0.95rem;
}

/* ================================================================
   FOOTER
   ================================================================ */

.site-footer {
  border-top: 1px solid var(--color-border);
  padding: var(--space-xl) var(--space-lg);
  margin-top: var(--space-2xl);
  background: linear-gradient(180deg, #eef2ef 0%, #e4eae6 100%);
}

.site-footer__grid {
  max-width: var(--max-width);
  margin: 0 auto;
  display: grid;
  gap: var(--space-xl);
  grid-template-columns: 1fr;
}

@media (min-width: 768px) {
  .site-footer__grid {
    grid-template-columns: repeat(auto-fit, minmax(220px, 1fr));
  }
}

.site-footer__name {
  font-family: var(--font-display);
  font-weight: 600;
  margin: 0 0 var(--space-xs);
}

.site-footer__tag {
  margin: 0;
  color: var(--color-text-muted);
  font-size: 0.95rem;
  max-width: 36ch;
}

.site-footer__heading {
  font-size: 0.75rem;
  font-weight: 700;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  margin: 0 0 var(--space-sm);
  color: var(--color-text-muted);
}

.site-footer__muted {
  font-size: 0.9rem;
  color: var(--color-text-muted);
  margin: 0;
}

.site-footer__muted code {
  font-size: 0.85em;
}

.site-footer__contact-link-wrap {
  margin: var(--space-sm) 0 0;
}

.social-list {
  list-style: none;
  margin: 0;
  padding: 0;
}

.social-list__link {
  color: var(--color-text);
  font-weight: 600;
  text-decoration: none;
}

.social-list__link:hover {
  text-decoration: underline;
}

.site-footer__legal {
  max-width: var(--max-width);
  margin: var(--space-xl) auto 0;
  padding-top: var(--space-lg);
  border-top: 1px solid var(--color-border);
  font-size: 0.85rem;
  color: var(--color-text-muted);
  text-align: center;
}

.site-footer__legal p {
  margin: 0 0 0.4rem;
}

.site-footer__legal p:last-child {
  margin-bottom: 0;
}

/* ================================================================
   CONTACT PAGE
   ================================================================ */

.contact-response-time {
  margin-top: calc(-1 * var(--space-md));
  margin-bottom: var(--space-lg);
  color: var(--color-text-muted);
  font-size: 0.95rem;
}

.contact-sub-copy {
  margin-top: var(--space-sm);
  font-size: 1rem;
  color: var(--color-text-muted);
  max-width: 58ch;
}

/* ================================================================
   DISCLAIMER
   ================================================================ */

.disclaimer-card {
  border: 1px solid rgba(20, 48, 40, 0.15);
  background: linear-gradient(180deg, #fafcfb 0%, #f2f7f4 100%);
  border-radius: var(--radius);
  padding: var(--space-md) var(--space-lg);
}

.disclaimer-card p {
  margin: 0;
  color: var(--color-text-muted);
}

.pub-title {
  font-weight: 600;
}

/* ================================================================
   SCIENCE PAGE
   ================================================================ */

.science-section {
  margin-bottom: var(--space-xl);
}

.science-section.prose {
  max-width: 68ch;
}

.science-section .section__title {
  font-family: var(--font-display);
  font-size: 1.5rem;
  font-weight: 600;
  margin: 0 0 var(--space-md);
}

.science-section p {
  margin: 0 0 var(--space-md);
  color: var(--color-text-muted);
  font-size: 1.05rem;
  line-height: 1.65;
}

.science-section p:last-child {
  margin-bottom: 0;
}

.pub-significance {
  display: block;
  margin-top: var(--space-xs);
  font-size: 0.9rem;
  color: var(--color-text-muted);
  font-style: italic;
}

/* ================================================================
   PIPELINE INDICATION CARDS (full-page)
   ================================================================ */

.pipeline-programs {
  margin-bottom: var(--space-xl);
}

.pipeline-indication-card {
  background: var(--color-surface);
  border: 1px solid var(--color-border);
  border-radius: var(--radius);
  padding: var(--space-lg);
  box-shadow: var(--shadow-sm);
  display: flex;
  flex-direction: column;
  min-height: 100%;
  transition: border-color 0.2s, box-shadow 0.25s, transform 0.25s;
  position: relative;
  overflow: hidden;
}

.pipeline-indication-card::before {
  content: "";
  position: absolute;
  top: 0;
  left: 0;
  right: 0;
  height: 3px;
  background: linear-gradient(90deg, var(--color-accent), #3aa892, transparent);
  opacity: 0;
  transition: opacity 0.3s;
}

.pipeline-indication-card:hover {
  border-color: rgba(11, 107, 88, 0.3);
  box-shadow: var(--shadow-md);
  transform: translateY(-3px);
}

.pipeline-indication-card:hover::before {
  opacity: 1;
}

.pipeline-indication-card__header {
  margin-bottom: var(--space-md);
}

.pipeline-indication-card__badge {
  display: inline-block;
  font-family: var(--font-body);
  font-size: 0.68rem;
  font-weight: 700;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  padding: 0.3rem 0.65rem;
  border-radius: var(--radius-pill);
  background: var(--color-accent-soft);
  color: var(--color-accent-hover);
  margin-bottom: var(--space-sm);
  border: 1px solid rgba(11, 107, 88, 0.12);
}

.pipeline-indication-card__name {
  font-family: var(--font-display);
  font-size: 1.35rem;
  font-weight: 600;
  margin: 0 0 var(--space-xs);
  color: var(--color-text);
}

.pipeline-indication-card__indication {
  font-size: 0.85rem;
  color: var(--color-accent-muted);
  font-weight: 600;
  margin: 0;
}

.pipeline-indication-card__summary {
  margin: 0;
  font-size: 0.98rem;
  color: var(--color-text-muted);
  line-height: 1.6;
  flex: 1;
}